Treating HABP/VABP

Choose VIBATIV for a proven clinical advantage and consistently high cure rates against S. aureus

Primary endpoint results from studies of VIBATIV in HABP/VABP1

In the Phase 3 ATTAIN studies, VIBATIV demonstrated similar cure rates to vancomycin in patients with HABP/VABP due to MRSA and MSSA.

Clinically evaluable population:
  • VIBATIV: 84.2%
  • Vancomycin: 80.7%
All-treated population:
  • VIBATIV: 58.9%
  • Vancomycin: 59.5%

In patients with HABP, more than 41% did not receive appropriate therapy and had higher mortality rates compared with patients receiving adequate therapy2


With a P value of 0.056, this comparison did not reach statistical significance.

In patients with VABP, more than 25% did not receive appropriate therapy until after 24 hours of diagnosis and had higher mortality rates compared with patients receiving adequate therapy3


Cure Rates

In the ATTAIN trials, VIBATIV provided higher cure rates vs vancomycin in HABP/VABP populations1,2


VIBATIV delivered significantly higher cure rates vs vancomycin in HABP/VABP due to any single Gram-positive pathogen or S. aureus with MIC ≥1 μg/mL.1,2


VIBATIV provided high cure rates vs vancomycin in HABP/VABP patients with infections due to MRSA or MSSA.2



VIBATIV demonstrated high levels in ELF and AM throughout 24 hours that exceeded the MIC90 for MRSA and MSSA (0.06 μg/mL)3

High levels of lung penetration


HABP/VABP and concurrent bacteremia

VIBATIV is the only anti-MRSA agent with data in the product label for HABP/VABP and concurrent S. aureus bacteremia1

Clinical cure rates for S. aureus bacteremia

Of the 797 patients in the Modified All-Treated (MAT) population with at least 1 Gram-positive respiratory pathogen at baseline4:

  • 73 patients had concurrent S. aureus bacteremia at baseline
    • 35 (8.5%) were treated with VIBATIV (21 for MRSA)
    • 38 (9.8%) were treated with vancomycin (24 for MRSA)
  • Clinical cure rates in these patients were 54.3% with VIBATIV and 47.4% with vancomycin
  • Given the limited sample size in this subgroup, the interpretation of these results is limited

Efficacy in challenging patients

Consistently favorable cure rates with VIBATIV vs vancomycin in important subgroups with HABP/VABP1

Baseline CPIS score >6


Clinically evaluable population

References: 1. Data on file. Theravance Biopharma Antibiotics, Inc. 2. Rubinstein E, Lalani T, Corey GR, et al, for the ATTAIN Study Group. Telavancin versus vancomycin for hospital-acquired pneumonia due to Gram-positive pathogens. Clin Infect Dis. 2011;52:31-40. 3. Gotfried MH, Shaw JP, Benton BM, et al. Intrapulmonary distribution of intravenous telavancin in healthy subjects and effect of pulmonary surfactant on in vitro activities of telavancin and other antibiotics. Antimicrob Agents Chemother. 2008;52:92-97. 4. VIBATIV [prescribing information]. South San Francisco, CA: Theravance Biopharma Antibiotics, Inc; May 2016.



VIBATIV is indicated for the treatment of adult patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates). VIBATIV should be reserved for use when alternative treatments are not suitable.


VIBATIV is indicated for the treatment of adult patients with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive microorganisms:

  • Staphylococcus aureus (including methicillin-susceptible and -resistant isolates)
  • Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S. constellatus), or
  • Enterococcus faecalis (vancomycin-susceptible isolates only)

Combination therapy may be clinically indicated if the documented or presumed pathogens include Gram-negative organisms.

Appropriate specimens for bacteriological examination should be obtained in order to isolate and identify the causative pathogens and to determine their susceptibility to telavancin. VIBATIV may be initiated as empiric therapy before results of these tests are known. To reduce the development of drug-resistant bacteria and maintain the effectiveness of VIBATIV and other antibacterial drugs, VIBATIV should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Important Safety Information


Patients with pre-existing moderate/severe renal impairment (CrCl ≤50 mL/min) who were treated with VIBATIV for hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia had increased mortality observed versus vancomycin. Use of VIBATIV in patients with pre-existing moderate/severe renal impairment (CrCl ≤50 mL/min) should be considered only when the anticipated benefit to the patient outweighs the potential risk.


New onset or worsening renal impairment occurred in patients who received VIBATIV. Renal adverse events were more likely to occur in patients with baseline comorbidities known to predispose patients to kidney dysfunction and in patients who received concomitant medications known to affect kidney function. Monitor renal function in all patients receiving VIBATIV prior to initiation of treatment, during treatment, and at the end of therapy. If renal function decreases, the benefit of continuing VIBATIV versus discontinuing and initiating therapy with an alternative agent should be assessed.

Fetal Risk

Women of childbearing potential should have a serum pregnancy test prior to administration of VIBATIV. Avoid use of VIBATIV during pregnancy unless the potential benefit to the patient outweighs the potential risk to the fetus. Adverse developmental outcomes observed in three animal species at clinically relevant doses raise concerns about potential adverse developmental outcomes in humans. If not already pregnant, women of childbearing potential should use effective contraception during VIBATIV treatment.


Intravenous unfractionated heparin sodium is contraindicated with VIBATIV administration due to artificially prolonged activated partial thromboplastin time (aPTT) test results for up to 18 hours after VIBATIV administration.

VIBATIV is contraindicated in patients with a known hypersensitivity to the drug.

Hypersensitivity Reactions

Serious and potentially fatal hypersensitivity reactions, including anaphylactic reactions, may occur after first or subsequent doses. VIBATIV should be used with caution in patients with known hypersensitivity to vancomycin.

Geriatric Use

Telavancin is substantially excreted by the kidney, and the risk of adverse reactions may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection in this age group.

Infusion Related Reactions

VIBATIV is a lipoglycopeptide antibacterial agent and should be administered over a period of 60 minutes to reduce the risk of infusion-related reactions. Rapid intravenous infusions of the glycopeptide class of antimicrobial agents can cause “Red-man Syndrome” like reactions including: flushing of the upper body, urticaria, pruritus, or rash.

QTc Prolongation

Caution is warranted when prescribing VIBATIV to patients taking drugs known to prolong the QT interval. In a study involving healthy volunteers, VIBATIV prolonged the QTc interval. Use of VIBATIV should be avoided in patients with congenital long QT syndrome, known prolongation of the QTc interval, uncompensated heart failure, or severe left ventricular hypertrophy.

Most Common Adverse Reactions

The most common adverse reactions (greater than or equal to 10% of patients treated with VIBATIV) were diarrhea, taste disturbance, nausea, vomiting, and foamy urine.

Please see full Prescribing Information including Boxed Warning and Medication Guide.